PET imaging for the evaluation of cerebral amyloid angiopathy: a systematic review

Abstract Purpose In the last years, role of PET imaging in assessment cerebral amyloid angiopathy (CAA) is emerging. this setting, some tracers have proven their utility for evaluation disease (mainly 11 C-Pittsburgh compound B [ C-PIB]), however, value other radiotracers has to be clarified. The aim systematic review is, therefore, assess CAA. Methods A wide literature search PubMed/MEDLINE, Scopus, Embase, Web Science and Cochrane library databases was made find relevant published articles about diagnostic performance Quality including risk bias applicability concerns carried out using QUADAS-2 evaluation. Results comprehensive computer revealed 651 articles. On reviewing titles abstracts, 622 were excluded because reported data not within field interest. Twenty-nine studies included review. general, with its CAA, differential diagnosis a correlation clinico-pathological features. With less evidence, 18F-fluorodeoxiglucose ( 18 F-FDG) tau starting emerge. Conclusion demonstrated particular, amiloid higher retention CAA patients, bleed, ability differentiate between related conditions (such as Alzheimer's disease) cerebrospinal fluid biomarkers.